Title : Identifying the pathological models of covid-19 disease - temporal staging of disease (shad vidha kriya kala model) and disease outcome model based on the principles of Ayurveda
Abstract:
Background: Global community is facing an unprecedented pandemic of novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome - Coronavirus 2 (SARS-CoV- 2). The prevalent gaps are variable host responses towards the infection. This research is a preliminary attempt to bridge this gap through exploring host-centric disease pathways and validating them in the diagnosed cases of COVID-19 disease. The models investigated in the study are Temporal Staging of Disease (Shad vidha Kriya Kala Model) and Disease Outcome model – A function of three variables.
Methods: A questionnaire-based, cross-sectional study was conducted in two cohorts of diagnosed cases of COVID–19. Study participants were subjected to a questionnaire to assess the temporal staging of COVID-19 disease in the subjects and to assess the relationship between the three determinants of the disease - exposure, clinical severity and Vyadhiksamatwa (immune status)
Results: In the study , COVID-19 disease was found to follow the temporal pattern (Model 1) described in Ayurveda and the staging include Sanchaya, Prakopa, Prasara , Sthana Samshraya and Bheda stages, further corresponding to 2.59 days, 2.7 days , 2.11 days , 4.09 days , 7 days and 15 days respectively. In the second model, clinical Severity was found strongly correlated with Immune status (with the value of Pearson Correlation - 0.740 significant at the 0.01 level (2-tailed).
Conclusions: The study reports host centric two pathological models of COVID-19 disease based on the principles of Ayurveda. The relationship between the variables was observed and they can be applied for preventive and therapeutic measures.
