Identifying the pathological models of covid-19 disease - temporal staging of disease (shad vidha kriya kala model) and disease outcome model based on the principles of Ayurveda

Title : Identifying the pathological models of covid-19 disease - temporal staging of disease (shad vidha kriya kala model) and disease outcome model based on the principles of Ayurveda

Abstract:

Background: Global community is facing an unprecedented pandemic of novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome - Coronavirus 2 (SARS-CoV- 2). The prevalent gaps are variable host responses towards the infection. This research is a preliminary attempt to bridge this gap through exploring host-centric disease pathways and validating them in the diagnosed cases of COVID-19 disease. The models investigated in the study are Temporal Staging of Disease (Shad vidha Kriya Kala Model) and Disease Outcome model – A function of three variables.

Methods: A questionnaire-based, cross-sectional study was conducted in two cohorts of diagnosed cases of COVID–19. Study participants were subjected to a questionnaire to assess the temporal staging of COVID-19 disease in the subjects and to assess the relationship between the three determinants of the disease - exposure, clinical severity and Vyadhiksamatwa (immune status)

Results: In the study , COVID-19 disease was found to follow the temporal pattern (Model 1) described in Ayurveda and the staging include Sanchaya, Prakopa, Prasara , Sthana Samshraya and Bheda stages, further corresponding to 2.59 days, 2.7 days , 2.11 days , 4.09 days , 7 days and 15 days respectively. In the second model, clinical Severity was found strongly correlated with Immune status (with the value of Pearson Correlation - 0.740 significant at the 0.01 level (2-tailed).

Conclusions: The study reports host centric two pathological models of COVID-19 disease based on the principles of Ayurveda. The relationship between the variables was observed and they can be applied for preventive and therapeutic measures.

Biography:

Charu sharma is a Primary investigator of 2 research projects – The title of the project “Evaluation of the Comparative Effectiveness of Ayurvedic management and conventional standard care in Gestational Diabetes Mellitus - An open label: Randomized Control Trial.” She is also the primary investigator in the project Identifying the pathological models of COVID- 19 in Ayurveda: Shatkriyakala and Vikar vighata; bhava abhava- A Cross Sectional Study. She has founded the first Ayurveda’s Ed-tech Startup - AyuScholar Education Pvt. Ltd. And educates Ayurveda doctors worldwide. She has been awarded with Dr Prakash Manglassery Memorial award 2021and Scholar of the year by research foundation. She has been awarded with various awards in scientific presentations. “A National Conference on Dinacharya and Ritucharya for public health promotion”. Scientific Poster Presentation at AHMA. She has also been awarded in National Seminar on Ayurvedic Management of Infertility Epigenetics of Recurrent Pregnancy Loss Windows of Opportunities via Integrative care in Ayurveda. She has been awarded with first prize for the award RE-DISCOVERING CONTRACEPTIVES -Windows of Opportunities via ethnopharmacological research and awarded first prize.