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Valencia, Spain
September 08-10, 2025
ICTM 2025

Pharmacological properties of Platycarpha glomerata extracts-(Thunb.) Less – a plant used to treat and manage elephantiasis

Siphamandla Lamula, Speaker at Traditional Medicine Conferences
University of Fort Hare, South Africa
Title : Pharmacological properties of Platycarpha glomerata extracts-(Thunb.) Less – a plant used to treat and manage elephantiasis

Abstract:

Platycarpha glomerata (Thunb.) Less. has recently became a plant species of interest to re-searchers due to its biological activities and less toxic effects. Therefore, the aim of the study seeks to evaluate the in vitro anticancer potential and phytochemical constituents of P. glomerata plant extracts. Phytochemical screening and FTIR were carried out using standard methods. The antioxidant activity was accessed by determining its ability to scavenge the DPPH radical, and nitric ox-ide radical, whereas the anticancer activity against prostate (DU-145 and PC-3), Human T-Lymphocyte (SKU-T), gastric adenocarcinoma (AGS), and human prostatic epithelial (PNTA1) cell line was evaluated using the MTT assay. The phytochemical analysis revealed the presence of tannins, flavonoids, saponins, steroids, terpenoids, and cardiac glycosides. The FTIR spectrum for the aqueous extract displayed characteristic peaks for O-H, C=O, C = C, and = C – H stretch. The aqueous, ethanol and methanol extracts showed significant dose-dependent DPPH radical scavenging capacity. The aqueous, ethanol and methanol extracts showed minimum NO scavenging activity of 4.3%, 9.6 % and 11.7 % at 2500 µg/mL. The water extract demonstrated good activity against S. aureus, E. coli and B. pumilus with the MIC of 0.195 mg/mL, respectively. The ethanol and methanol extracts significantly reduced the percentage proliferation of DU-145, PC-3 and SKU-T cells at 100 μg/mL. These extracts demonstrated strong dose-dependent DPPH and NO scavenging, antibacterial and cell proliferation inhibition activities. The strong bioactivity of the P. glomerata makes it a good candidate for isolation and identification of active compounds for anti-cancer and related illnesses.

Biography:

Dr. Siphamandla Qhubekani Lamula is a postdoctoral fellow at the University of Fort Hare, Alice, South Africa. Dr. Lamula obtained an undergraduate degree in Botany at the University of Free State in 2012, received an Honors degree in Botany in 2013, completed an MSc degree in Botany in 2015, and further completed a doctoral degree in Environmental Sciences at North-West University in 2020. Dr. Lamula’s research interests mainly center on the use of traditional medicinal plants as a source of medicine. Dr. Lamula is also a member of the South African Association of Botanists, the Nematology Society of Southern Africa, and the Society for Medicinal Plants and Economic Development.

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