Title : Theory and application of chinmedomics
Abstract:
Evaluation of the efficacy of traditional Chinese medicines (TCMs) is an important prerequisite for discovering effective substances, lead compounds, and quality markers (Q markers). At present, there is an urgent need to develop a biological language that can act as a bridge for the scientific elaboration of the efficacy of TCMs, and to further highlight the significant value of TCM. Chinese medicinal formulae and syndromes are two essential parts of TCM that directly relate to its efficacy. Syndromes and formulae have been taken as the research objects of our team. We have integrated the serum pharmacochemistry of the TCM approach with metabolomics and established an innovative chinmedomics strategy, which is able to explore syndrome biomarkers and evaluate TCM efficacy in order to discover effective substances from TCMs. Chinmedomics approach has been widely used in identifying the candidate biomarkers of a syndrome and revealing the efficacy of the related formula in order to the discovery of lead compounds and Q markers from TCMs. We have already performed a great deal of concrete work in chinmedomics to bridge the gap between Chinese and Western medicine, and to provide a powerful approach to enhance the scientific value of TCM theory and clinical practice.
