HYBRID EVENT: You can participate in person at Valencia, Spain or Virtually from your home or work.
Hybrid Event
September 18-20, 2023 | Valencia, Spain
ICTM 2019

Chihiro Sugita

Chihiro Sugita, Speaker at Traditional Medicine Conference
Kyushu University of Health and Welfare, Japan
Title : The effects of Brazilian propolis and contained flavonoids on platelet aggregation and blood coagulation system


Propolis has been used worldwide as a dietary supplement for the purpose of health promotion. Recently, some studies have shown that a diet in fruit and vegetables containing flavonoid reduced the risk of thrombosis and cardiovascular disease. We hypothesized Brazilian propolis (AF-08) contained some flavonoids has antithrombotic action. We determined the effects of AF-08 and three flavonoids (apigenin, kaempferol and chrysin) contained in AF08 against blood coagulation system and platelet aggregation. Plasma from healthy volunteers (The study protocol was approved by our institutional ethics committees.) were incubated with serial-diluted AF-08, apigenin, kaempferol, or chrysin for 10 minutes. The effects of AF-08, apigenin, kaempferol and chrysin on blood coagulation system and platelet function were evaluated by prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet aggregation, respectively. Consequently, AF-08, apigenin, and chrysin significantly inhibited collagen-induced platelet aggregation in human plasma. However, they did not affect PT and APTT. Kaempferol did not affect in all measured parameters. These results suggest that AF-08, apigenin, and chrysin inhibit platelet aggregation without affecting blood coagulation system. Therefore, AF-08, apigenin, and chrysin might have potential to suppress platelet-based arterial thrombosis.


Dr. Sugita graduated Faculty of Pharmacy, Kyushu University of Health and Welfare in 2007. She then joined the researches of thrombus at Department of Pathology, Faculty of Medicine, University of Miyazaki. She received her PhD degree in 2013 at the same institution. From the same year, she is working as a Research Associate in the Department of Biochemistry, Kyushu University of Health and Welfare.