HYBRID EVENT: You can participate in person at Paris, France or Virtually from your home or work.
Paris, France
September 01-02, 2022 | Paris, France
ICTM 2019

Effects of an aqueous Morinda citrifolia fruit extract on indomethacin induced gastric ulcer in rats

Sonsawan Kongpuckdee, Speaker at Ethnomedicine Conferences
Prince Of Songkla University, Thailand
Title : Effects of an aqueous Morinda citrifolia fruit extract on indomethacin induced gastric ulcer in rats

Abstract:

Non-steroidal anti-inflammatory drugs (NSAIDs) have been accepted as a major cause of GU (80% of the cases) that results in impaired quality of life, work loss, and high–cost medical care. The tissue inflammatory response seems to be related to an excess release of a number of inflammatory mediators especially inflammatory prostaglandins (PGs) derived from cyclooxygenase-2 (COX-2) and nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS). Nowadays, the use of herbal or traditional medicines is becoming popular in GU due to the potent antioxidant and anti-inflammatory activities of their biologically active compounds. The mature unripe fruit of Morinda citrifolia (Linn.) or noni (Rubiaceae), is one of a tropical medicinal plant that has been used in Thai folk medicine as a reliever of heartburn or stomachache. Previous studies in vitro and in vivo systems had shown that an aqueous M. citrifolia fruit extract (AMFE) possessed potent anti-inflammatory property in suppressing iNOS and COX-2 activities including antiulcer property against ethanol-, serotonin- and acetic acid-induced gastric ulcer (GU) in rats. Therefore, the efficacy of AMFE in treatment of GU induced by an oral administration of indomethacin (NSAID) (30 mg/kg) for 5 h schedule in rats was further evaluated. The sum of the area (mm2) of all haemorrhagic ulcerations for each stomach was used as ulcer index. The expression of COX-1, COX-2 and iNOS expression in the gastric ulcerated tissue was also evaluated using quantitative real-time polymerase chain reaction (qRT-PCR) analysis. The obtained results showed that an oral administration of AMFE at the dose of 1.25 g/kg [equivalent to 0.806 mg of scopoletin (a biomarker)] for 3 days significantly decreased ulcer index with a comparable ulcer healing efficacy to that of lansoprazole (a standard antiulcer agent). The qRT-PCR resullts also showed that AMFE exerted a comparable potency to lansoprazole in down-regulation of iNOS and COX–2 gene expression and in up-regulation of COX-1 gene expression. The finding indicated that AMFE may be beneficial as a potential therapeutic agent for NSAIDs-induced GU mainly through its anti-inflammatory and gastroprotective activities.

Biography:

Miss Sonsawan Kongpuckdee graduated Bachelor of Thai Traditional Medicine and Master of Pharmaceutical Sciencesfrom Prince of Songkla University, Thailand in 2012 and 2017, respectively. Now, she is studying PhD degree of Pharmaceutical Sciences at the Faculty of Pharmaceutical science, Prince of Songkla University, Thailand, She has received one Thailand Petty Patent (14974) of topical bioadhesive gel formulation containing phytosome complex of AMFE.

Watsapp