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Paris, France
September 01-02, 2022 | Paris, France
ICTM 2019

Anti-HIV-1 protease activity of the crude extracts and isolated compounds from Auricularia polytricha

Chanin Sillapachaiyaporn, Speaker at Traditional Medicine Conferences
Chulalongkorn University, Thailand
Title : Anti-HIV-1 protease activity of the crude extracts and isolated compounds from Auricularia polytricha

Abstract:

Acquired immunodeficiency syndrome (AIDS) is caused by the Human immunodeficiency virus type-1 (HIV1). HIV-1 protease (PR) is an essential enzyme for the HIV replication. Auricularia polytricha (AP) is an edible mushroom that has several important therapeutic properties. The sequential hexane (APH), ethanol (APE) and water (APW) extracts from AP were screened for inhibitory activity against HIV-1 PR. APH exhibited significant inhibition on HIV-1 PR activity. Phytochemical constituents of APH were purified by chromatography and structurally elucidated by 1D and 2D NMR, HRMS, FTIR, and GC/MS techniques. The isolated compounds were identified to be two triacylglycerols, linoleic acid and ergosterol. All isolated compounds showed significant inhibition of HIV-1 PR activity. The findings from this study suggest that AP is a good source of fatty esters, fatty acids and ergosterol which exhibit antiHIV-1 properties by blocking HIV-1 PR. These important biological results warrant further development of AP as an alternative antiretroviral drug

Biography:

Mr. Chanin Sillapachaiyaporn studied Medical Technology in Faculty of Allied Health Sciences, Chulalongkorn University, Thailand in 2015. Then he graduated master’s degree in Program of Clinical Biochemistry and Molecular Medicine from Faculty of Allied Health Sciences, Chulalongkorn University, Thailand in 2019. Now, he is studying PhD program at the same institution. He has studied on biological activity of natural products such as anti-HIV-1, immunomodulatory and neuroprotective activities.

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