Title : Preventive and therapeutic effects of Fufang Ejiao Jiang on Chronic Fatigue Syndrome
Abstract:
Chronic Fatigue Syndrome (CFS), also referred to as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is a complex disorder characterized by persistent fatigue, impaired cognitive function, sleep disturbances, and reduced physical capacity. Current therapeutic options remain limited, and increasing attention has been directed toward complementary and integrative approaches. Fufang Ejiao Jiang (FFEJ), a classical Traditional Chinese Medicine (TCM) formulation composed primarily of Ejiao and multiple qi- and blood-tonifying herbs, has been widely used in China for conditions associated with fatigue, weakness, and suboptimal health status. From the perspective of TCM theory, CFS is closely associated with deficiencies of qi, blood, spleen, and kidney functions, often accompanied by emotional dysregulation and imbalance between yin and yang. FFEJ is traditionally used to nourish blood, replenish qi, improve vitality, and restore systemic balance. Recent pharmacological and clinical studies suggest that FFEJ may exert anti-fatigue, immunomodulatory, antioxidative, hematopoietic, and neuroendocrine regulatory effects. Experimental evidence indicates that the formulation may improve mitochondrial energy metabolism, reduce inflammatory cytokine activity, enhance stress tolerance, and alleviate fatigue-related behavioral symptoms. Clinical observations have reported improvements in fatigue severity, sleep quality, appetite, exercise tolerance, and quality of life among patients receiving FFEJ as part of integrative management strategies. Furthermore, its favorable safety profile and long history of clinical application make it a promising candidate for long-term supportive care. This presentation reviews the traditional theoretical basis, modern pharmacological mechanisms, and emerging clinical evidence regarding the application of Fufang Ejiao Jiang in the prevention and treatment of chronic fatigue syndrome. The integration of traditional holistic approaches with contemporary biomedical research may provide new perspectives for addressing chronic fatigue and related disorders in the era of personalized and integrative medicine.
